|
Indications and Dosage
Oral
Urinary tract infections Adult: 750 mg every 12 hr.
|
|
Contraindications
Hypersensitivity. Severe renal impairment. Pregnancy and lactation. G6PD deficiency. Children. Convulsive conditions.
|
|
Special Precautions
Impaired renal or hepatic function; exposure to strong sunlight. Elderly.
|
|
Adverse Reactions
Urinary stones, muscle pain, hypersensivity reactions (e.g. rash, urticaria, pruritus, photosensitivity, leukopenia, eosinophilia), nausea, vomiting, anorexia, epigastric pain, abdominal pain, diarrhoea, metallic taste, increased LFTs, insomnia, anxiety, nervousness, confusion, vertigo, somnolence, headache, peripheral neuropathy, paraesthesia, photophobia, blurred vision, disturbances in accommodation, diplopia, convulsions, hallucination.
|
|
Action
Description: Oxolinic acid is a quinolone antibacterial agent with properties similar to nalidixic acid. It interferes with bacterial DNA replication probably by inactivating bacterial DNA gyrase (type II topoisomerase).
Pharmacokinetics: Absorption: Absorbed in the GI tract. Peak plasma concentration in 30-60 min. Distribution: Protein-binding: 80%. Metabolism: Hepatic. Excretion: Via urine. Half-life: 4-6 hr. |
|
MIMS Class
|
Sign Out
